Step 1: Calculate Difficulty Defense Damage Reduction Scalars
Defense subtracts a flat amount from incoming hit damage based on your difficulty mode: Classic Mode reduces damage by (Defense x 0.5); Expert Mode reduces damage by (Defense x 0.75); and Master Mode reduces damage by (Defense x 1.0). In Master Mode, every single point of monster defense deducts 1 full point of damage from your weapon strikes.
Step 2: Stack Armor Penetration Accessories to Negate Boss Armor
Armor Penetration ignores monster defense point-for-point. Formula: Effective Defense = max(0, Boss Defense - Armor Pen). Equipping the Shark Tooth Necklace (+5) and Stinger Necklace (+5), drinking Sharpening Station buff (+12 for melee), and inflicting Ichor (-15 boss defense) reduces target defense by 37 points, doubling damage output on rapid-fire weapons.
Step 3: Factor in Calamity Mod Boss Damage Reduction (DR%)
In Calamity Mod (tModLoader), bosses possess an innate Damage Reduction percentage (DR%) that applies multiplicatively after defense is subtracted. For example, Supreme Calamitas has 35% DR; an attack dealing 100 damage after defense is reduced to 65 damage. Fast multi-hit weapons are balanced through soft damage caps.